Treatment depleting my-HSCs rejuvenates aged mice immune system

Summary: Researchers developed a treatment to rejuvenate the immunological system by depleting myeloid-biased hematopoietic stem cells (my-HSCs) in aged mice. This led to increased lymphocyte progenitors, improved immune responses to infections, and reduced levels of pro-inflammatory proteins. The study identified potential targets for therapeutic my-HSC reduction and highlighted the importance of balancing myeloid and lymphoid lineage cells for optimal immune function.

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