Bats' longevity genes offer clues for fighting cancer and aging

A new study in Nature reveals that bats' longevity and virus tolerance are genetically linked, offering potential clues for human health. Researchers suggest these mechanisms could inspire new ways to fight cancer and age-related diseases. The study, led by Juan Manuel Vazquez at UC Berkeley, examined 32 bat species, focusing on the Myotis genus, where Brandt's bat lives up to 42 years. Bats use viral tolerance, suppressing inflammation to carry viruses, and have evolved extra immune gene copies like PKR. Long-lived bats clear damaged cells to prevent cancer, and their immune systems avoid decline with age. Vazquez says this suggests human diseases of ageing and infection may be tackled through shared biological pathways, potentially improving immunity against tumors and stress.