TLR9 crucial for memory formation and DNA repair

Summary: A study in Nature reveals that learning triggers double-stranded DNA damage in hippocampal neurons, followed by repair mediated by toll-like receptor 9 (TLR9), crucial for memory formation. Murine models showed TLR9's role in DNA repair, inflammatory responses, and memory formation. TLR9 knockout led to memory impairments. Understanding these processes could aid in addressing cognitive and neurodegenerative disorders. TLR9 plays a key role in memory formation and neuronal repair.

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