Wistar Institute researchers reveal key role of INST10 in neural cell development

Researchers at the Wistar Institute have discovered new details about how neural cells develop. Their study focuses on a molecular complex called Integrator, specifically the subunit INST10, which plays a crucial role in early neural development. The team found that INST10 is more abundant in neural cells than in other cell types. When INST10 levels were reduced, cells shifted away from becoming neurons and began to develop into other cell types, indicating its importance in maintaining neural identity. This research enhances the understanding of neurogenesis, the formation of the nervous system, and may help in studying neurodevelopmental disorders linked to mutations in the Integrator complex. The findings were published in *Nature Cell Biology*.