Rising fungal diseases pose global health crisis

Fungal diseases are on the rise, causing 3.8 million global deaths annually. Aspergillus infections are increasing due to longer lifespans and a hotter world. Treatments are limited, with only four major antifungal drug classes available. Olorofim, a new drug, faces resistance from fungicide ipflufenoquin. Drug resistance is a growing concern, leading to decreased research and development by pharmaceutical companies. The World Health Organization considers the lack of new antibiotics and antifungals a crisis.