Researchers identify key protein INST10 in neural cell development

Researchers at the Wistar Institute have identified the protein subunit INST10 as essential for guiding pluripotent stem cells to develop into neural cells. Lower levels of INST10 lead to a loss of neural identity, causing cells to adopt other fates. The study highlights INST10's role in maintaining neuronal characteristics and its connection to neurodevelopmental disorders. This research provides new insights into the molecular processes involved in neurogenesis, which is crucial for understanding early brain development. The findings were published in *Nature Cell Biology*. The research suggests that the Integrator protein complex, particularly INST10, plays a key role in directing cell fate during early neural development.