Oropouche virus infection controlled by rapid immune response preventing neurological damage

A new study reveals a specific immune cell response in mice controls Oropouche virus infection and prevents neurological damage. Researchers identified that rapid antibody production by marginal zone B cells, activated by the MyD88 protein, is crucial for neutralizing the virus and preventing it from reaching the brain. This discovery, published in eBioMedicine, offers insights for developing future therapies and vaccines against Oropouche fever, which has seen a significant case increase in Brazil this year.