Nobel Prize honors discovery of microRNA and its role in gene regulation

Victor Ambros and Gary Ruvkun won the Nobel Prize for their discovery of microRNA (miRNA) and its role in gene regulation. Their work, initially overlooked, is now recognized as crucial for understanding cellular processes across all life forms. Since their discovery, researchers have identified thousands of miRNAs that regulate about 60% of human genes. Currently, 581 clinical trials involving miRNAs are registered in the U.S., with advancements in delivery methods improving their therapeutic potential. Despite past challenges, including safety concerns in early trials, the recognition of miRNAs may enhance their future applications in medicine. This Nobel Prize marks the fifth awarded for RNA research, highlighting RNA's importance in biology.