New York-Chicago is USA's busiest air route

The busiest domestic air route in the US for July 2025 is New York LaGuardia to Chicago O'Hare, with approximately 307,000 seats scheduled. This route surpasses others in the country by seat capacity. Following closely behind, the New York JFK to Los Angeles route is the second busiest, while the third busiest is Las Vegas to Los Angeles. Atlanta to Orlando and Los Angeles to Chicago O'Hare complete the top five. The rankings, based on seat numbers, are subject to change. The US domestic routes are not as busy as international routes, with the busiest global route being in South Korea.