New technique identifies Alzheimer's-vulnerable memory cells

Researchers from The University of Texas at Arlington and the University of California–San Francisco have developed a new brain-mapping technique. This method identifies memory-related brain cells that are vulnerable to tau protein buildup, linked to Alzheimer's disease. The study focused on the hippocampus, revealing that specific neurons are more affected by tau accumulation. In contrast, oligodendrocytes, which insulate nerve fibers, showed less vulnerability, suggesting a protective role against tau buildup. The findings indicate that the distribution of cell types in the brain may be a better predictor of tau accumulation than genetic factors. This research could help target vulnerable cells and genes related to Alzheimer's disease progression.