New gene-editing tool enhances precision in targeting genetic mutations

A new gene-editing tool called Helicase-Assisted Continuous Editing (HACE) allows scientists to make precise mutations in specific genes without altering the entire genome. This method combines helicase enzymes with CRISPR technology for targeted editing. HACE has successfully identified mutations linked to drug resistance in cancer genes and splicing defects in blood cancers. This advancement enhances the ability to study gene functions and could lead to new therapeutic discoveries. Unlike traditional methods that broadly mutate genes, HACE targets specific locations, improving precision in genetic research. The tool's development marks a significant step forward in genomic editing capabilities.