New brain map reveals cellular roots of Parkinson's, Alzheimer's, and schizophrenia

Scientists have created the first 3D cellular atlas of the human basal ganglia, a deep brain region controlling movement, behavior, and emotions, offering new insights into disorders like Parkinson's, Alzheimer's, and schizophrenia. The map, built from donor tissue using spatial transcriptomics, details each cell's location and gene activity, enabling precise identification of genetic risks and supporting more accurate diagnoses and treatments. It is part of the BRAIN Initiative launched in 2014. Additional studies identified a neuron linked to schizophrenia and bipolar disorder, revealed genetic changes tied to autism, and described a less invasive gene therapy for Parkinson's tremors tested in animals. All data is openly shared.