Nebraska students publish research on human immunity evolution

Three students at the University of Nebraska-Lincoln have made significant contributions to science as undergraduates. Vanessa Hubing, Avery Marquis, and Chanasei Ziemann have co-authored two research papers about how human immune systems have evolved over time. This achievement is notable because first authorship is uncommon for undergraduate students. The trio worked under Luwen Zhang, a virologist at the university. They participated in a program that supports undergraduate research with stipends. Their studies focused on interferon regulatory factors (IRFs), which are crucial for the immune response. One of their papers details how vertebrates developed advanced immune systems with the evolution of jaws. The second paper discusses a "pseudogene" that may have helped primates fight germs millions of years ago. Through their research, the students used advanced computer analysis to explore genetic sequences. They received guidance from Zhang and his colleague, Etsuko Moriyama. The students faced a learning curve with the technology but ultimately succeeded and felt accomplished by their results. Their research is important for understanding human defenses against diseases and could provide insights into immune-related illnesses. Zhang noted that their work has gained attention in the field of immunity. He and Moriyama are seeking funding to continue this research. Hubing, Marquis, and Ziemann have expressed their passion for science and medicine. Ziemann plans to attend graduate school, Marquis is interested in animal health care, and Hubing aims to apply to a physician assistant program. All three students enjoyed their experience in Zhang's lab, challenging the notion that top-tier research only occurs at prestigious institutions. They are proud to show that significant scientific work happens in Nebraska.