MIT develops long-lasting drug delivery method with crystals

MIT engineers have created a new method to deliver drugs that could reduce the number of injections needed. This method uses tiny crystals injected into the body. Once inside, these crystals form a drug "depot" that can last for several months or even years. This system is helpful for long-lasting contraceptives and other medications that need to be administered over time. The drugs are mixed in a liquid before injection, making it possible to use a smaller, thinner needle, which is more comfortable for patients. Giovanni Traverso, a professor at MIT, explained that this method offers a controlled and long-lasting release of medication. Current injections often require larger needles or frequent doses. In contrast, this new method aims to combine the benefits of long-term implants with the convenience of self-administered injections. Researchers developed this method with a contraceptive drug called levonorgestrel. They found that using a specific solvent allowed the drug crystals to form a compact implant beneath the skin after they were injected. This method uses a minimal amount of polymer, making the injections easier. The team tested the method on rats and found that the drug depots stayed stable for three months, with most of the drug still available. They believe these depots could actually last for more than a year and are now planning further studies. The new delivery system might also work for treating other medical conditions, such as mental health disorders and infectious diseases. The researchers are preparing to test this approach in humans to see how effective it can be in a clinical setting.