Leptin reverses diabetic ketoacidosis without insulin

Leptin, a hormone signaling energy sufficiency, can reverse diabetic ketoacidosis without insulin, researchers confirm. The brain, misinterpreting low leptin as a lack of fuel, triggers DKA. Leptin administration in animal models normalized blood sugar and ketone levels, suggesting brain-based diabetes treatment. This discovery challenges the century-old insulin-centric model of type 1 diabetes and could lead to insulin-free therapies.