Autism risk genes converge into two opposing brain activity patterns

Researchers found that over 1,200 autism-risk genes converge into two distinct patterns of brain gene activity, revealing opposing molecular states that could guide precision therapy for autism. The two patterns represent opposite biological pathways, potentially explaining varied autism symptoms and treatment responses. This discovery suggests autism may be split into two brain states rather than one uniform condition. These findings could enable more targeted treatments tailored to an individual's specific genetic and molecular profile, moving beyond a one-size-fits-all approach to autism care.