HE4 biomarker predicts risk in AHF with CKD

Dove Medical Press April 2, 2024, 08:00 AM UTC

Summary: Acute heart failure (AHF) combined with chronic kidney disease (CKD) poses a significant risk, with readmission rates up to 44% and a mortality rate of 30% within a year. Human epididymis protein 4 (HE4) emerges as a promising biomarker for prognosis, showing a positive correlation with NT-proBNP and a negative correlation with eGFR. Patients with HE4 levels >276.15 pmol/L have a 2.52-fold higher risk of adverse events.

Full article

Article metrics
Significance6.0
Scale7.0
Magnitude7.5
Potential8.0
Novelty7.0
Actionability8.5
Immediacy9.0
Positivity6.0
Credibility8.0

Also covered in: