Smart nanoparticles deliver drugs to treat heart attack inflammation

Summary: Every 40 seconds, a heart attack occurs in the U.S. with 300,000 patients not receiving post-attack surgery. Jianjun Guan's team at Washington University aims to use smart nanoparticles to deliver anti-inflammatory and anti-fibrosis drugs directly to the heart. The $2.1 million NIH-funded project combines M2 macrophage secretome and a peptide inhibitor to target inflammation and fibrosis. The goal is to develop a self-administered treatment for heart attack patients.

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