Risk management strategies reduce mortality in BRCA1/2 carriers

Summary: Two cohort studies in JAMA Oncology found that risk management strategies, such as MRI surveillance for breast cancer and bilateral salpingo-oophorectomy (BSO) for ovarian cancer, significantly reduced mortality in women with BRCA1/2 sequence variations. MRI surveillance was associated with a 77% reduction in breast cancer mortality, while BSO was linked to a 68% decrease in all-cause mortality. These findings support the use of these strategies and highlight the need for equitable access and coverage.

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