Unfolded protein response pathway targets bone weakness in cancer patients

medicalxpress.com

New research identifies the unfolded protein response (UPR) pathway as a potential target for treating bone weakness in cancer patients. The UPR pathway, a cellular stress response, is hijacked by cancer cells, leading to compromised bone structure and increased fracture risk in various bone cancers and metastatic tumors. Targeting specific UPR cascades with emerging drugs shows promise in reducing skeletal-related events and killing bone tumors, though further research is needed for targeted efficacy.


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Unfolded protein response pathway targets bone weakness in cancer patients | News Minimalist