Two cancer drugs reverse Alzheimer's damage in mice

Two existing cancer drugs, letrozole and irinotecan, have shown promise in reversing Alzheimer's-related brain damage in mice. The drugs, already FDA-approved for cancer treatment, were identified through computational analysis of gene expression changes in Alzheimer's. When used together in mouse models, they reduced tau protein buildup and improved learning and memory. This research offers a potential new therapeutic strategy for Alzheimer's, a disease affecting millions globally, with hopes for future human clinical trials.