The overlooked hinge of immunoglobulin G controls antibody structure and function

phys.org

The lower hinge of immunoglobulin G (IgG) antibodies acts as a crucial control hub, according to new research. A study found that deleting a single amino acid in this region transforms a full antibody into a stable half-molecule with altered immune activity. This discovery offers a blueprint for developing next-generation antibody therapies with precisely tailored immune effects for various diseases.


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The overlooked hinge of immunoglobulin G controls antibody structure and function | News Minimalist