Targeting telomere damage improves cancer immunotherapy

Targeting telomere damage in T cells shows promise for enhancing cancer immunotherapy effectiveness. New research reveals that tumor environments cause mitochondria to damage telomeres, leading to T cell exhaustion. Preventing this damage with antioxidants can restore T cell function. This discovery could be integrated into CAR-T therapy to improve its efficacy against cancer. Researchers are developing a human-compatible approach for clinical trials.