Study shows fat cells retain memory of obesity, leading to rapid weight regain

A study from ETH Zurich shows that fat cells have an epigenetic memory of obesity, which can lead to quick weight regain after dieting. This memory persists in both humans and mice, highlighting challenges in maintaining weight loss. Researchers found that obesity alters gene expression in fat cells, allowing them to easily regain fat when exposed to high-fat diets. Similar patterns were observed in fat tissue from individuals who had gastric bypass surgery. The study suggests that preventing obesity, especially in youth, is crucial for long-term health. Experts recommend sustainable weight management through balanced diets, regular exercise, and gradual weight loss.