Scientists identify enzyme that drives rapid DNA rewiring in cancer

sciencedaily.com

Scientists identified the enzyme N4BP2 as the trigger for chromothripsis, a chaotic DNA-shattering event in about a quarter of cancers. This enzyme breaks apart DNA within cellular structures, causing rapid genetic changes that help tumors adapt and resist treatment. Blocking N4BP2 significantly reduced this genomic destruction in cancer cells. Chromothripsis leads to rapid tumor evolution and is linked to aggressive cancers and extrachromosomal DNA, which promotes tumor growth and therapy resistance.


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Scientists identify enzyme that drives rapid DNA rewiring in cancer | News Minimalist