Scientists find 5,000+ genetic variants aiding cancer growth

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In a study published in Nature Genetics, researchers identified over 5,000 genetic variants in the BAP1 gene related to cancer and neurodevelopment. They used saturation genome editing to analyze these variations, improving precision medicine efforts. Disruptive BAP1 mutations were linked to cancer and increased IGF-1 levels. The refined SGE method showed high sensitivity and specificity, enhancing understanding of BAP1 function and potential therapeutic targets.


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