RNA enzyme Mettl1 plays vital role in heart cell energy shift after birth

Researchers have identified the RNA enzyme Mettl1 as crucial for heart cell energy metabolism after birth. This enzyme facilitates the shift from glucose to fatty acid oxidation, essential for heart cell maturation. The study found that Mettl1 regulates ketogenesis, which is vital for producing energy in neonatal hearts. Loss of Mettl1 activity led to reduced ketone production and impaired metabolic transition, resulting in immature heart cell characteristics. By using genetically modified mice and various experimental techniques, the researchers demonstrated that Mettl1 influences gene expression and metabolic pathways. These findings highlight the potential of targeting Mettl1 or ketogenesis in treating heart disorders.