Researchers improve CRISPR gene editing in neurons and nondividing cells

phys.org

Neurons and nondividing cells repair DNA differently than dividing cells, impacting CRISPR gene editing outcomes. This discovery explains challenges in treating brain disorders with gene editing, as Cas9 persists longer in neurons, potentially causing off-target edits. Researchers developed methods to control these repair mechanisms, improving the safety and efficacy of gene editing therapies for various diseases.


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Researchers improve CRISPR gene editing in neurons and nondividing cells | News Minimalist