Researchers enhance Parkinson's disease studies with advanced live-cell analysis techniques

Researchers are using advanced live-cell analysis techniques to study Parkinson's Disease (PD) more effectively. This approach allows for real-time monitoring of neuronal models, overcoming limitations of traditional methods that often disrupt cellular processes. The Incucyte® Neurite Outgrowth Assay and Phagocytosis Assay enable scientists to visualize and quantify neuronal changes and microglial activity without harming the cells. These tools facilitate high-throughput screening for neuroprotective agents and insights into neurotoxicity. A new co-culture model combining rat neurons and astrocytes has been developed to assess the effects of neurotoxins like 6-hydroxydopamine. This model shows varying impacts on neurite length across different brain regions, enhancing understanding of PD pathology.