Researchers create living interface to enhance neurovascular remodeling in tissue regeneration

Researchers at the Shenzhen Institutes of Advanced Technology have developed a new living interface that enhances neurovascular remodeling. This interface can secrete bioactive exosomes with adjustable contents and miRNA, promoting tissue regeneration more effectively than previous methods. The new system, called LIFES, combines a specialized material layer with living stem cells. It allows for sustained exosome release over about 192 hours, with contents that can be programmed to support different stages of healing. This advancement addresses limitations of existing exosome delivery methods, which often have short lifespans and inconsistent bioactivity. The study's findings could lead to improvements in biomedical devices and regenerative medicine.