Researchers camouflage gene scissors to improve cancer therapy research

Researchers have developed a "stealth mode" for CRISPR gene editing technology, making it invisible to the mouse immune system. This innovation aims to improve the accuracy of cancer research. The bacterial components of CRISPR are recognized as foreign by the mouse immune system, distorting research results. The new method temporarily exposes cells to CRISPR and uses modified reporter genes to avoid immune detection. This breakthrough allows for more accurate CRISPR screens in mice with intact immune systems, potentially leading to new cancer therapies and applications in personalized medicine.