Placenta changes linked to schizophrenia genetic risks

An international study has found a link between changes in the placenta and the risk of mental health disorders like schizophrenia, bipolar disorder, and major depression. The research included 28 scientists from 18 institutions in Europe and the U.S. The study shows that specific DNA changes in the placenta can affect genes related to these psychiatric conditions. This suggests that genetic risks may start even before birth. The researchers focused on a process called DNA methylation, which involves adding small chemical groups to DNA to regulate gene activity without changing the DNA itself. Schizophrenia, bipolar disorder, and major depression were most strongly connected to the modifications found in the placenta. Other conditions like ADHD and autism showed some links, but they were not as significant. The findings support the idea that these mental health disorders may develop during early brain growth, with the placenta playing a crucial role. The results could lead to new ways to prevent and treat these disorders. If risk factors can be identified before birth, doctors might be able to intervene early and develop personalized prevention strategies. Understanding the timing and location of genetic factors could also improve treatment decisions later in life. This research marks an important step in uncovering the biological causes of mental health disorders and could pave the way for better methods of early detection and treatment. The study took place at IRLab, involving researchers with expertise in both placental health and epigenetics.