PHGDH redirects breast cancer macrophages to fight tumors

A new study reveals the metabolic enzyme PHGDH plays a previously unknown role in breast cancer immunity, shifting immune cells toward tumor-fighting behavior. Researchers found that PHGDH translocates to the nucleus of macrophages, suppressing genes that promote an immunosuppressive state. This action redirects macrophages from supporting tumors to fighting them, impacting tumor growth. The findings suggest new therapeutic strategies targeting PHGDH to rewire the tumor microenvironment and enhance immunotherapy effectiveness. PHGDH levels could also serve as a biomarker for patient stratification.