Osteoporosis drug blocks spinal disc damage in zebrafish

An osteoporosis drug blocked spinal disc damage in zebrafish with a faulty collagen gene, reducing mineral buildup and fusion, researchers reported. The fish developed spine abnormalities resembling human disc disease as tissue hardened before minerals formed. Problems with fat metabolism, phosphate control, and mTOR signaling were identified as contributing factors. No drugs currently halt disc degeneration; surgery remains sole long-term treatment. Researchers say findings highlight promising drug targets, with funding from Arthritis UK and BBSRC.