New TOR inhibitor rapalink-1 extends lifespan in fission yeast

A new TOR inhibitor, rapalink-1, has been shown to significantly extend lifespan in fission yeast. Researchers discovered that rapalink-1 slows cell growth and works through the TORC1 pathway. The study also identified a new metabolic feedback loop involving agmatinases that regulates TOR activity and influences aging. This research suggests a link between diet, the microbiome, and aging, potentially offering new strategies for healthy aging and disease treatment.