New drug and enzyme class show anti-aging properties in yeast

A new drug, rapalink-1, has been found to extend lifespan in yeast by inhibiting the TOR pathway, a key regulator of growth and aging. Researchers discovered a previously unknown metabolic feedback loop involving agmatinases that regulates TOR activity. Loss of agmatinase function led to faster growth but premature aging. The study suggests that diet and gut microbes, which influence agmatine levels, may impact aging through this pathway, though caution is advised regarding agmatine supplementation.