New atlas maps brain cell proteins to advance neurological disease research

Scientists created the first brain lysosome protein atlas, identifying proteins in different brain cell types. This atlas could advance understanding of neurological diseases. The atlas maps 790 lysosomal proteins and their distribution across neurons, astrocytes, oligodendrocytes, and microglia. Researchers linked it to new insights into Alzheimer's and Parkinson's disease. This research builds on previous work developing methods to isolate and study lysosomes. The atlas is now publicly available, enabling further investigation into lysosomal dysfunction and disease.