Mpox replicates in the brain of an HIV-positive man, NIH researchers report

Mpox virus was found replicating in the brain of a man with advanced HIV who died from the infection. Researchers at the National Institutes of Health discovered the virus infecting brain tissue and multiplying, suggesting mpox can spread beyond typical skin lesions. The case also revealed drug resistance mutations. This finding, detailed in a preprint released Thursday, highlights the virus's potential to persist and evolve, even as global health programs for such infections are reduced.