MIT researchers map dynamic fuzzy coat surrounding tau protein fibrils

news-medical.net

MIT researchers have mapped the dynamic "fuzzy coat" surrounding Tau protein fibrils, a key feature in Alzheimer's disease. Using advanced NMR spectroscopy, scientists deciphered the structure of this disordered outer layer, which influences how Tau interacts with other molecules and is crucial for drug development. This breakthrough offers new insights into Tau tangles and could aid in creating therapies to prevent protein buildup in the brain.


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