MIT chemists reveal structure of tau protein's fuzzy coat using NMR

MIT chemists have deciphered the structure of the "fuzzy coat" surrounding Tau proteins using NMR. This breakthrough could lead to new Alzheimer's treatments. The fuzzy coat, a disordered outer layer of Tau protein tangles, is crucial for understanding how these proteins interact. Its structure was previously difficult to determine due to its dynamic nature. This finding offers insights into Tau protein aggregation, a hallmark of Alzheimer's and other neurodegenerative diseases, potentially guiding drug development efforts.