Man overcomes rare orgasm allergy with new treatment in Israel

A 22-year-old man suffered from a rare condition called post-orgasmic illness syndrome (POIS), experiencing severe symptoms like muscle pain and brain fog after orgasms since age 14. Previous treatments, including antidepressants, were ineffective. After consulting doctors in Israel, he was prescribed a combination of antihistamines, anti-inflammatories, and steroids, which helped but did not fully resolve his cognitive issues. Eventually, he was treated with omalizumab, a medication for severe asthma, which completely alleviated his symptoms. Despite testing negative for a semen allergy, doctors believe his condition may involve an autoimmune response. The man is now symptom-free and able to engage in relationships without additional medications.