International study identifies core biological pathways in knee osteoarthritis

Osteoarthritis is a single disease with common biological pathways, not multiple subtypes, according to a large international study. The research analyzed over 1,300 knee joint fluid samples, revealing core pathways related to tissue injury and repair, though variations exist due to factors like obesity. These findings offer a molecular map for developing more targeted and effective treatments for the widespread condition, which currently lacks disease-modifying therapies.