Hunan study finds low HIV integrase inhibitor resistance after treatment failure

dovepress.com

A study in Hunan Province found low HIV integrase inhibitor resistance after treatment failure, with 4% of 125 patients carrying resistance mutations, supporting the drugs’ high genetic barrier. Resistance appeared in 1.64% of bictegravir users and 6.78% of dolutegravir users. Network analysis identified 15 transmission clusters; subtype G viruses were significantly more likely to cluster, indicating potential local spread. Researchers sequenced integrase genes from 125 adults failing INSTI-based regimens between 2019 and 2024. They recommend routine resistance testing and molecular surveillance despite low prevalence and small sample limitations.


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Hunan study finds low HIV integrase inhibitor resistance after treatment failure | News Minimalist