Harvard scientist: first 150-year-old may already be alive

Harvard scientist David Sinclair claims the first 150-year-old human may already be alive, as his research on reversing cellular aging has moved from animal experiments to an early human trial. Sinclair's work uses partial cellular reprogramming with Yamanaka factors to restore lost epigenetic information, showing vision reversal in mice and monkeys. In June 2026, the first patient received this therapy for glaucoma in a trial by LifeBiosciences, testing actual reversal rather than slowing of aging. Sinclair's team is also using AI to screen trillions of molecules for potential age-reversing pills, which could cost about $100 monthly versus $2 million for gene therapy. Preclinical mouse studies showed reduced biological age, though human safety remains unproven.