Grin2A gene mutations increase schizophrenia risk

Mutations in the Grin2A gene are linked to an increased risk of schizophrenia and other mental disorders. Researchers found that variants of Grin2A reduce the activity of the NMDA receptor, crucial for neuronal communication, thereby raising the risk of mental health conditions. This discovery challenges the view of mental disorders as solely polygenic and suggests potential future prevention therapies, including L-serine treatment.