Frank's sign: a diagonal earlobe crease as a potential cardiovascular risk indicator

g1.globo.com (Portuguese)

A diagonal earlobe crease, known as Frank's sign, may indicate increased cardiovascular risk. This sign is not a diagnosis but a potential warning sign. It is associated with premature blood vessel aging and atherosclerosis, especially when present in younger individuals or with other risk factors. Medical evaluation is recommended if Frank's sign is present, involving checks for high blood pressure, cholesterol, and other risk factors to assess heart health.


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Frank's sign: a diagonal earlobe crease as a potential cardiovascular risk indicator | News Minimalist