Engineered immunosuppressive dendritic cells protect against cardiac remodeling in preclinical models

Engineered immunosuppressive dendritic cells show promise in preventing cardiac remodeling. These specialized cells, called iCDCs, reduced inflammation and fibrosis in mouse models of heart damage. They also improved heart function and blood flow. The therapy was also tested in non-human primates after heart attack, showing similar positive results without systemic toxicity.