Energetic water confined in molecular cavities supercharges chemical bonds

Confined water molecules within molecular cavities can supercharge chemical bonds, potentially revolutionizing drug design. Researchers demonstrated that this "energetic water," squeezed into tight spaces, releases stored energy when displaced, strengthening new molecular bonds. This phenomenon acts as a molecular power assist. The findings settle a debate about water's role in confined spaces and have implications for biological systems, drug design, and materials science.