DMT shows promise in rapidly reducing depression symptoms

es.wired.com (Spanish) — February 17, 2026 at 12:02 AM UTC

DMT, a compound in ayahuasca, shows promise in rapidly reducing depression symptoms. A clinical trial found intravenous DMT, combined with therapy, significantly lowered depression scores for up to three months in adults. Mystical experiences during treatment correlated with greater symptom reduction. The study, published in Nature Medicine, involved 34 adults and suggests DMT offers a faster, safer alternative to placebo for severe depression, potentially revolutionizing psychedelic therapy with its short duration.

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