Nanoparticles block cholesterol uptake, reduce chemotherapy-resistant ovarian cancer growth

Northwestern Medicine scientists discovered a way to destroy chemotherapy-resistant ovarian cancer by blocking its cholesterol uptake with synthetic nanoparticles. The treatment reduced ovarian tumor growth by over 50% in human cells and animal models. The research, funded by the U.S. Department of Defense, aims to develop a combination of nanoparticles and traditional chemotherapy. The study was published in Advanced Science and involved 14 Northwestern authors.